期刊
JOURNAL OF BONE AND MINERAL RESEARCH
卷 22, 期 9, 页码 1419-1425出版社
AMER SOC BONE & MINERAL RES
DOI: 10.1359/jbmr.070607
关键词
strontium ranelate; osteoporosis; biomechanics; bone quality; nanoindentation
Beside its influence on determinants of bone strength (geometry, microarchitecture), which is likely to be related to a cellular effect, strontium ranelate improves bone tissue quality as evaluated by nanoindentation, increasing elastic modulus, hardness, and dissipated energy in vertebrae of rats treated for 104 wk with daily dose from 0 to 900 mg/kg.
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