期刊
ANALYST
卷 138, 期 23, 页码 7070-7074出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3an01406a
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资金
- European Community [227012]
- UK EPSRC [EP/C009592/1]
- Engineering and Physical Sciences Research Council [EP/K031317/1, EP/D032210/1, GR/S91512/01, EP/E035728/1] Funding Source: researchfish
- EPSRC [EP/D032210/1, EP/K031317/1, EP/E035728/1] Funding Source: UKRI
The cell-to-cell variation of gold nanoparticle (GNP) uptake is important for therapeutic applications. We directly counted the GNPs in hundreds of individual cells, and showed that the large variation from cell-to-cell could be directly modelled by assuming log-normal distributions of both cell mass and GNP rate of uptake. This was true for GNPs non-specifically bound to fetal bovine serum or conjugated to a cell penetrating peptide. Within a population of cells, GNP content varied naturally by a factor greater than 10 between individual cells.
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