期刊
EARLY HUMAN DEVELOPMENT
卷 83, 期 9, 页码 563-566出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.earlhumdev.2006.11.001
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Objectives: We aimed to establish the earliest gestational age at which fetal DNA in maternal plasma could be detected and whether this was reliable at 12-13 weeks' gestation. Study design: A prospective observational cohort study of 32 pregnancies either after IVF or before prenatal diagnosis by CVS. Maternal blood was taken and RT-PCR was carried out to detect the multi-copy Y chromosome associated DSY14 gene. The end point was gender as assessed at delivery or on karyotype. Results: Y signal was obtained as early as 14 days post conception (4 weeks' gestation) and has a good prediction rate by 12 weeks' gestation. Conclusion: Free fetal DNA allows very early prediction of fetal sex in some cases and could be useful for clinical use for X-linked conditions by the end of the first trimester. (C) 2006 Elsevier Ireland Ltd. All rights reserved.
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