期刊
ANALYST
卷 138, 期 21, 页码 6282-6286出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3an01427d
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资金
- National Natural Science Foundation of China [91027010, 21073073]
- National Instrumentation Program of the Ministry of Science and Technology of China [2011YQ03012408]
We describe a novel 'switch-off' biosensing strategy for the detection of chymotrypsin based on surface plasmon resonance (SPR) and surface-enhanced Raman scattering (SERS) spectroscopy. This approach analyzes the fingerprint spectrum of the chymotrypsin-catalyzed substrate. The lowest probed concentration is 0.4 nM for chymotrypsin.
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