期刊
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
卷 34, 期 3, 页码 302-303出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.ejvs.2007.04.011
关键词
abdominal aortic aneurysm; randomised clinical trial; statins; matrix Metalloproteases; cytokines
To investigate whether statins reduce the concentration of MMP-9 in the aortic wall, we randomised patients undergoing elective open repair of an abdominal aortic aneurysm (AAA) to a pre-operative course of either simvastatin or placebo. MMPs in aortic biopsies were measured using gelatin zymography. Although recruitment closed early because of increasing statin use among eligible patients, with only 21 patients we demonstrated a 40% reduction in MMP-9 levels in the AAA wall in patients randomised to simvastatin. This provides a possible molecular mechanism to explain the reportedly beneficial effects of statins to slow AAA growth. (c) 2007 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.
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