期刊
FOOD AND BIOPRODUCTS PROCESSING
卷 85, 期 C3, 页码 284-290出版社
ELSEVIER
DOI: 10.1205/fbp07030
关键词
casein; oleic acid; coating; cross-linking; sustained release
The use of casein as a novel film-forming agent, capable of functioning as a pharmaceutical tablet coat, was assessed. Diltiazem HCI core tablets were coated with casein using a pan coater and the efficacy of four different plasticizing agents (glycerol, triethyl citrate, dibutyl sebacate and oleic acid) in producing a continuous tablet-coat were evaluated. Interestingly, only those films formed using oleic acid as a plasticizing agent were capable of producing a continuous, acceptable coat. Consequently, the drug dissolution properties of casein/oleic acid film-coated tablets in pH 1.2 and pH 6.8 media were further investigated. Post-coating thermal treatment (60, 80 and 100 degrees C) was shown to have a significant effect on the properties of the casein-oleic acid films. Diltiazem HCl drug release at pH 1.2 was found to decrease with increasing post-coating heat treatment temperature. Additionally, only coated tablets that were subjected to post-coating heat treatment at 100 degrees C showed sustained drug release properties at pH 6.8, which may be attributed to casein cross-linking.
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