期刊
ANALYST
卷 138, 期 6, 页码 1886-1890出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3an36590e
关键词
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资金
- National Science Fund for Distinguished Young Scholars [20925520]
- National Natural Science Foundation of China [61001035, J1103512]
- Leading Academic Discipline Project of Shanghai Municipal Education Commission [J50108]
Oxytetracycline (OTC), a broad-spectrum antibiotic, has been extensively used as a food additive for livestock. Its extensive use has greatly increased the risk of chronic drug abuse and has also increased the risk of the resulting diseases. Therefore, in light of this emerging situation, the detection of OTC in both food and livestock is very important to reduce the risks and for diagnosis purposes. In this work, we have proposed an electrochemical aptasensor to quantify OTC. The biosensor shows considerable sensitivity and selectivity, and it can be easily operated and regenerated. Furthermore, for the first time, we have shown that an electrochemical aptasensor can be directly used to detect OTC in mouse blood serum and urine. This biosensor has the potential to aid in the analysis of residual OTC levels, as well as providing more pharmacokinetic information in the future.
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