期刊
NATURE CHEMICAL BIOLOGY
卷 3, 期 9, 页码 557-558出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.2007.22
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资金
- NIAID NIH HHS [AI47818] Funding Source: Medline
Polyketides are clinically important natural products that often require elaborate organic syntheses owing to their complex chemical structures. Here we report the multienzyme total synthesis of the Streptomyces maritimus enterocin and wailupemycin bacteriostatic agents in a single reaction vessel from simple benzoate and malonate substrates. To our knowledge, our results represent the first in vitro assembly of a complete type II polyketide synthase enzymatic pathway to natural products.
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