期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 51, 期 9, 页码 3413-3415出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01571-06
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Three clinically relevant intermittent regimens, and a continuous infusion, of colistin were simulated in an in vitro pharmacokinetic/pharmacodynamic model against two colistin-heteroresistant strains of Acinetobacter baumannii. Extensive initial killing was followed by regrowth as early as 6 h later; bacterial density in the 24-to 72-h period was within 1 log(10) CFU/ml of growth control. Population analysis profiles revealed extensive emergence of resistant subpopulations regardless of the collistin regimen.
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