期刊
JOURNAL OF PSYCHOSOMATIC RESEARCH
卷 63, 期 3, 页码 233-239出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jpsychores.2007.05.012
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资金
- NIA NIH HHS [P01 AG018784-01A1, P01 AG018784-05S1, P01 AG018784-04S2, P01 AG018784-04, P01 AG018784-02, P01 AG018784-05, P01 AG018784-04S1, P01 AG018784-03, P01 AG018784, P1AG18784, P01 AG018784-02S1] Funding Source: Medline
Background: There is mixed evidence regarding the possible association between a history of stressful or traumatic life events and more rapid breast cancer progression. Method: Retrospective reports of past experiences of traumatic life events were assessed among 94 women with metastatic or recurrent breast cancer. A traumatic event assessment was conducted using the event-screening question from the posttraumatic stress disorder (PTSD) module of the Structured Clinical Interview for the DSM-IV-TR (SCID; 2002). Each reported event was judged by two independent raters to determine whether it met DSM-IV-TR PTSD A1 criteria for a traumatic event. Those events that did not meet such criteria were designated stressful events. Results: Nearly 42% of the women in the sample were judged to have experienced one or more traumatic events; 28.7% reported only stressful events. A Kruskal-Wallis test found significant differences in disease-free interval among the three groups [chi(2) (2, N=94)=6.09, P < 05]. Planned comparisons revealed a significantly longer disease-free interval among women who had reported no traumatic or stressful life events (median=62 months) compared to those who had experienced one or more stressful or traumatic life events (combined median=31 months). Conclusions: A history of stressful or traumatic life events may reduce host resistance to tumor growth. These findings are consistent with a possible long-lasting effect of previous life stress on stress response systems such as the hypothalamic-pituitary-adrenal (HPA) axis. (c) 2007 Elsevier Inc. All rights reserved.
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