期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 14, 期 9, 页码 869-871出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb1283
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资金
- NHGRI NIH HHS [HG003523] Funding Source: Medline
- NIGMS NIH HHS [GM064786, GM60398] Funding Source: Medline
Polycomb proteins are required for maintenance of silent chromatin states via histone H3 Lys27 trimethylation ( H3K27me3) in animals, but homologs are not found in plant genomes. Using a DamID- chip method, we found that the Arabidopsis thaliana chromodomain- containing protein LHP1 colocalizes with H3K27me3 genome- wide. The LHP1 chromodomain also binds H3K27me3 with high affinity, suggesting that LHP1 has functions similar to those of Polycomb.
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