期刊
ANALYST
卷 137, 期 3, 页码 595-600出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2an15780b
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资金
- NIH [GM 5R01GM085291]
- DOD (U.S. Army Medical Research and Command) [W81XWH-08-1-0065]
- Purdue University Center for Cancer Research and Oncological Sciences Center in Discovery Park at Purdue
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM085291] Funding Source: NIH RePORTER
A convenient and fast method for quantifying urea in biofluids is demonstrated using NMR analysis and the solvent water signal as a concentration reference. The urea concentration can be accurately determined with errors less than 3% between 1 mM and 50 mM, and less than 2% above 50 mM in urine and serum. The method is promising for various applications with advantages of simplicity, high accuracy, and fast non-destructive detection. With an ability to measure other metabolites simultaneously, this NMR method is also likely to find applications in metabolic profiling and system biology.
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