Studies on the synthesis of some new substituted benzylamino and phenyl-acrylamido-methyl flavone derivatives

The synthesis and biological activity of a new series of 2-{3-[substituted benzylamino-methyl)-phenyl]-4H-benzopyrane-4-one (IVa-e) and N-substituted benzyl-N-[3-(4-oxo-4H-benzopyrane-2-yl)benzyl]-3-phenyl-acrylamide (Va-e) derivatives are reported. The synthesized compounds were tested in vitro for antifungal and antibacterial activities. Compound IVa showed the best antifungal activity compared with miconazole (CAS 22916-47-8). Compound IVc indicated the best antibacterial activity compared with the control drug ampicillin (CAS 69-53-4).