期刊
BIOLOGICAL & PHARMACEUTICAL BULLETIN
卷 30, 期 9, 页码 1808-1812出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.30.1808
关键词
deoxynivalenol; chick embryo; fatty body; immunosuppression
Food mycotoxin deoxynivalenol (vomitoxin, DON), produced by Fusarium grantinearuin and E culmorum can induce rapid diminution of lymphoid tissues and lymphopenia in the growing chickens and mammals. We first investigated the direct acute effects of DON on the chick immune-related embryo tissues such as embryonic liver and spleen. Direct DON administration into the embryonic eggs caused toxin accumulation in liver in a time-dependent manner. Electron microscopic observation showed a notable accumulation of fat droplet in the liver tissue and the re-exposed hatched chicken showed more distinguishing enlarged fat globules, so-called fatty cysts like human steatosis. Regarding effects of deoxynivalenol on the chick embryonic spleen, fatty change was also observed in splenocytes. Functionally, mitogen-stimulated cellular and Immoral lympho-proliferations were suppressed in the DON-treated embryo. Conclusively, acute direct exposure to deoxynivalenol in the chick embryo caused toxic histological alterations in the liver and spleen and suppressed in vitro lymphoblastogenesis.
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