期刊
MOLECULES
卷 12, 期 9, 页码 2130-2139出版社
MDPI
DOI: 10.3390/12092130
关键词
acetylcholineesterase; Agrimonia pilosa; quercetin; tiliroside; 3-methoxyquercetin; quercitrin.
资金
- National Research Foundation of Korea [과06A1503] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
In a bioassay-guided search for acetylcholinesterase (AChE) inhibitors from 180 medicinal plants, an ethyl acetate extract of whole plants of Agrimonia pilosa ledeb yielded tiliroside (1), 3-methoxy quercetin (2), quercitrin (3) and quercetin (4). We report herein for the first time that all four flavonol compounds showed significant inhibitory effects on AChE, particularly quercetin (4), which showed twice the activity of dehydroevodiamine (DHED).
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