期刊
ACTA CIRURGICA BRASILEIRA
卷 22, 期 5, 页码 351-354出版社
ACTA CIRURGICA BRASILEIRA
DOI: 10.1590/S0102-86502007000500005
关键词
physiological effects of drugs; fluoxetine; depression; animal experimentation
类别
Purpose: To compare the effects of the antidepressant drugs duloxetine and fluoxetine on depressive behaviors in rodents. Methods: Eighteen male Wistar rats were given systemic injections of duloxetine, fluoxetine, or saline prior to a Forced Swimming Test (FST). Immobility and number of stops were measured. Results: Rats given injections of fluoxetine displayed significantly less immobility (p = 0.02) and fewer stops than the control group (p = 0.003). Duloxetine significantly reduced the number of stops (p = 0.003), but did not effect immobility (p = 0.48). Conclusion: Duloxetine and fluoxetine reduced depressive behaviors in the Forced FST. However, our findings suggest that fluoxetine is more effective than duloxetine.
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