4.6 Article

IGF-I receptor is required for the anabolic actions of parathyroid hormone on bone

期刊

JOURNAL OF BONE AND MINERAL RESEARCH
卷 22, 期 9, 页码 1329-1337

出版社

WILEY
DOI: 10.1359/JBMR.070517

关键词

PTH; IGF-I signaling; osteoprogenitor; proliferation; bone formation rate

资金

  1. NIAMS NIH HHS [R01 AR055924] Funding Source: Medline
  2. NIDDK NIH HHS [R01 DK054793, R01 DK54793] Funding Source: Medline

向作者/读者索取更多资源

We showed that the IGF-IR-null mutation in mature osteoblasts leads to less bone and decreased periosteal bone formation and impaired the stimulatory effects of PTH on osteoprogenitor cell proliferation and differentiation.

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