期刊
FEMS MICROBIOLOGY LETTERS
卷 274, 期 2, 页码 311-315出版社
BLACKWELL PUBLISHING
DOI: 10.1111/j.1574-6968.2007.00846.x
关键词
scandium; antibiotic production; Streptomyces
类别
Despite their importance in the chemical industry, the significance of rare earths in biology has been largely overlooked. Here, it is reported that the rare earth, scandium (Sc), causes antibiotic overproduction by 2-25-fold when added at a low concentration (10-100 mu M) to cultures of Streptomyces coelicolor A3(2) (actinorhodin producer), Streptomyces antibioticus (actinomycin producer), and Streptomyces griseus (streptomycin producer). Not just for enhancement of antibiotic production, scandium was also effective in activating the dormant ability to produce actinorhodin in Streptomyces lividans. The effects of scandium were exerted at the level of transcription of pathway-specific positive regulatory genes, as demonstrated by marked up-regulation of actII-ORF4 in S. coelicolor cells exposed to this element. The bacterial alarmone, guanosine 5'-diphosphate 3'-diphosphate, was essential for actinorhodin overproduction provoked by scandium.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据