期刊
DEVELOPMENTAL DYNAMICS
卷 236, 期 9, 页码 2627-2635出版社
WILEY
DOI: 10.1002/dvdy.21259
关键词
dystroglycan; basement membrane; muscle; mouse
资金
- Wellcome Trust [GR077544AIA] Funding Source: Medline
Using immunohistochemistry, we have examined P-Dystroglycan protein distribution in the mouse embryo at embryonic stages E9.5 to E11.5. Our data show that Dystroglycan expression correlates with basement membranes in many tissues, such as the notochord, neural tube, promesonephros, and myotome. In the myotome, we describe the timing of Dystroglycan protein re-distribution at the surface of myogenic precursor cells as basement membrane assembles into a continuous sheet. We also report on non-basement-membrane-associated Dystroglycan expression in the floor plate and the myocardium. This distribution often corresponds to sites of expression previously reported in adults, suggesting that Dystroglycan is continuously produced during development.
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