期刊
MAGNETIC RESONANCE IN CHEMISTRY
卷 45, 期 9, 页码 777-780出版社
WILEY
DOI: 10.1002/mrc.2035
关键词
NMR; H-1 NMR; C-13 NMR; paecilin A; paecilin B
Two new natural products, named paecilin A (1) and B (2), together with two known compounds secalonic acid D (3) and (11)-cytochalasa-6(12),13-diene-1,21-dione-16,18-dimethyl-7-hydroxy-10-phenyl-(7S*,13E,16S*,18S*) (4), were isolated from the mangrove endophytic fungus, Paecilomyces sp. (tree 1-7) from the South China Sea. 1D and 2D NMR experiments including COSY, HMQC, and HMBC were used for the determination of their structures. In our cytotoxicity assays, secalonic D (3) showed cytotoxicity toward KB cells with IC50 < 1 mu g ml(-1) and inhibiting human topoisomerase I with IC50 at 0.16 mu mol ml(-1).1, 2, and 4 showed no activity to KB cells. Copyright (C) 2007 John Wiley & Sons, Ltd.
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