期刊
BEHAVIOURAL PHARMACOLOGY
卷 18, 期 5-6, 页码 507-513出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/FBP.0b013e3282ee2a91
关键词
cognition; fluoxetine; hippocampus; learning; Morris water maze; object recognition; Pavlovian; rat; spatial
It is generally assumed that fluoxetine does not produce cognitive impairments, based on observations that fluoxetine-treated animals do not show impairment in learning the spatial water-maze task. As fluoxetine has different effects on different brain regions and as learning is not a unitary phenomenon, it may be the case that fluoxetine has different effects on different types of learning and memory paradigms. In this study, 15 male Sprague-Dawley rats were given chronic injections of either fluoxetine or saline and received training in two hippocampal-independent tasks in addition to a spatial water-maze task. The two hippocampal-independent tasks were a short-delay appetitive Pavlovian-conditioning task and an object-recognition task. The results showed that the fluoxetine-injected rats did not show any impairment relative to the saline controls in either the acquisition or the retention phases of the water-maze task, but were significantly impaired in both of the hippocampal-independent tasks. Fluoxetine-injected rats spent significantly less time exploring the novel object in the object-recognition task and took longer to learn the association between the conditional stimulus and the appetitive unconditional stimulus in the appetitive Pavlovian-conditioning task.
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