期刊
ANALYST
卷 135, 期 5, 页码 887-894出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b920385k
关键词
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资金
- EPSRC Life Science Interface Scheme [EP/E039855/1]
- MIMITrade mark (Manchester: Integrating Medicine and Innovative Technology)
- EPSRC [EP/E039855/1] Funding Source: UKRI
- MRC [G0900871] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/E039855/1] Funding Source: researchfish
- Medical Research Council [G0900871] Funding Source: researchfish
Interest in developing robust, quicker and easier diagnostic tests for cancer has lead to an increased use of Fourier transform infrared (FTIR) spectroscopy to meet that need. In this study we present the use of different experimental modes of infrared spectroscopy to investigate the RWPE human prostate epithelial cell line family which are derived from the same source but differ in their mode of transformation and their mode of invasive phenotype. Importantly, analysis of the infrared spectra obtained using different experimental modes of infrared spectroscopy produces similar results. The RWPE family of cell lines can be separated into groups based upon the method of cell transformation rather than the resulting invasiveness/aggressiveness of the cell line. The study also demonstrates the possibility of using a genetic algorithm as a possible standardised pre-processing step and raises the important question of the usefulness of cell lines to create a biochemical model of prostate cancer progression.
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