期刊
ANALYST
卷 135, 期 3, 页码 577-582出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b921187j
关键词
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资金
- NSF of China [20935005, 90813032, 20875092]
- Ministry of Science and Technology of China [2008AA02Z206, 2010CB933502]
- the Chinese Academy of Sciences
A highly specific ferrocene-based fluorescent probe, (9-anthryl)ethenylferrocene, has been designed, synthesized and characterized for fluorescence imaging of hypochlorous acid (HOCl) in live cells. The design strategy for the probe is based on the strong quenching effect of electron-donor ferrocene on anthracene fluorescence via an intramolecular charge transfer process, and is accomplished through constructing the conjugated molecule by using a cleavable double bond as a linker. The double bond in the probe reacts selectively with HOCl rather than the other reactive oxygen species (e. g., (OH)-O-center dot, (center dot)O2(-), O-1(2), and H2O2) in pH 7.4, accompanied by more than 100-fold fluorescence enhancement. Moreover, the probe is cell membrane permeable, and its applicability has been successfully demonstrated for fluorescence imaging of HOCl in HeLa cells.
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