期刊
JOURNAL OF VIROLOGY
卷 81, 期 17, 页码 9268-9278出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00650-07
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资金
- NIAID NIH HHS [AI054207, R21 AI054207] Funding Source: Medline
- NINDS NIH HHS [NS37277, R01 NS037277] Funding Source: Medline
The Sydney Blood Bank Cohort (SBBC) consists of eight blood transfusion recipients infected with nef-attenuated human immunodeficiency virus type 1 (HIV-1) acquired from a single donor. Here, we show that viral phenotypes and antibody responses differ considerably between individual cohort members, despite the single source of infection. Replication of isolated virus varied from barely detectable to similar to that of the wild-type virus, and virus isolated from five SBBC members showed coreceptor usage signatures unique to each individual. Higher viral loads and stronger neutralizing antibody responses were associated with better-replicating viral strains, and detectable viral replication was essential for the development of strong and sustained humoral immune responses. Despite the presence of strong neutralizing antibodies in a number of SBBC members, disease progression was not prevented, and each cohort member studied displayed a unique outcome of infection with nef-attenuated HIV-1.
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