期刊
BRITISH JOURNAL OF DERMATOLOGY
卷 157, 期 3, 页码 531-539出版社
WILEY
DOI: 10.1111/j.1365-2133.2007.08057.x
关键词
CD4+CD25+FOXP3+regulatory T cells; cutaneous melanocytic lesions; immunohistochemistry; tumour-infiltrating lymphocytes
类别
Background CD4+ CD25+ FOXP3+ regulatory T cells ( Tregs) are thought to induce immunotolerance in melanoma. They have not yet been investigated in the entire spectrum of melanocytic cutaneous lesions within a tumour site. Objectives To evaluate CD4+ CD25+ FOXP3+ Tregs among tumour- infiltrating lymphocytes in cutaneous melanocytic lesions. Methods We analysed 128 lesions ( 10 benign junctional common naevi, 10 benign compound common naevi, 10 compound Spitz naevi, 10 junctional atypical naevi, 20 compound atypical naevi, 20 radial growth phase melanomas, 30 vertical growth phase melanomas and 18 melanoma metastases). Tregs were identified by CD25- FOXP3 double immunostains. Results This study indicates that CD4+ / CD25+ FOXP3+ Tregs are present in all groups of lesions. Junctional atypical naevi, compound atypical naevi and radial growth phase melanomas showed the highest percentages of CD4+ CD25+ FOXP3+ Tregs ( junctional atypical naevi vs. junctional common naevi, compound common naevi, compound Spitz naevi, melanoma metastases: P < 0 0001; junctional atypical naevi vs. vertical growth phase melanomas: P = 0 001; compound atypical naevi vs. junctional common naevi, compound common naevi: P < 0 0001; compound atypical naevi vs. compound Spitz naevi, melanoma metastases: P = 0 002; compound atypical naevi vs. vertical growth phase melanomas: P = 0 02; radial growth phase melanomas vs. junctional common naevi, compound common naevi, compound Spitz naevi, melanoma metastases: P < 0 0001; radial growth phase melanomas vs. vertical growth phase melanomas: P = 0 008). Conclusions The strong prevalence of CD25+ FOXP3+ Tregs both in junctional and compound atypical naevi and radial growth phase melanomas, suggests that they induce immunotolerance early during melanoma genesis, favouring melanoma growth. Their evaluation within a tumour site could be useful for prognostic and therapeutic purposes.
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