期刊
JOURNAL OF NATURAL PRODUCTS
卷 70, 期 9, 页码 1406-1409出版社
AMER CHEMICAL SOC
DOI: 10.1021/np060621r
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资金
- NCI NIH HHS [CA44848, CA67775] Funding Source: Medline
- NCRR NIH HHS [S10RR017768] Funding Source: Medline
Two new cytotoxic quinones of the angucycline class, marmycins A and B (1, 2), were isolated from the culture broth of a marine sediment-derived actinomycete related to the genus Streptomyces. The gross structures and absolute configurations of both compounds were determined by spectroscopic and crystallographic methods. Marmycin A (1) displayed significant cytotoxicity against several cancer cell lines, some at nanomolar concentrations; while compound 2, a chloro analogue of 1, was less potent. For marmycin A (1), tumor cell cytotoxicity appeared to coincide with induction of modest apoptosis and arrest in the G1 phase of the cell cycle.
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