期刊
EUROPEAN HEART JOURNAL SUPPLEMENTS
卷 9, 期 G, 页码 G3-G8出版社
OXFORD UNIV PRESS
DOI: 10.1093/eurheartj/sum047
关键词
QT study; QT/QTc prolongation; drug safety; pro-arrhythmia; Torsade de pointes; delayed repolarization
The ability of some non-cardiac drugs to alter cardiac repolarization and thereby increase the likelihood of cardiac arrhythmias, in particular life-threatening torsades de pointes, has led regulatory agencies to request that modifications of the QT interval, manifesting repolarization changes, should be intensively investigated in every drug developed. However, although prolongation of the QT interval is a relatively easily measured marker of repolarization changes, it is widely viewed as a poor surrogate of the arrhythmogenic potential of a drug. Despite intensive and costly investigation, the prediction of pro-arrhythmic risk based on pre-clinical and clinical data therefore remains imperfect. How QT interval relates to the safety of non-cardiac drugs, and how physicians can best integrate pre-clinical and clinical information in assessment of the risk profile of a drug, remain somewhat open questions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据