期刊
PHOTOCHEMISTRY AND PHOTOBIOLOGY
卷 83, 期 5, 页码 1006-1015出版社
WILEY
DOI: 10.1111/j.1751-1097.2007.00092.x
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资金
- NCI NIH HHS [CA98902] Funding Source: Medline
- NIBIB NIH HHS [EB0022064] Funding Source: Medline
Mono-(L)-aspartylchlorin-e(6) (also known as Talaporfin, NPe6, MACE, and most recently LS-11) is a potent sensitizer for photodynamic therapy that is currently undergoing clinical trials. Using a combination of unambiguous partial synthesis from pheophytin-a and methyl pheophorbide-a, NMR spectroscopy, and single crystal X-ray diffraction, the structure of mono-(L)-aspartylchlorin-e(6) is definitively shown to be the isomer in which the aspartyl residue is attached at the 15(2)-side chain position. This conclusion is contrary to earlier assumptions, but affirms the conclusions of a study based on NMR spectroscopy; a rationale for the unique formation of the 15(2)-aspartyl derivative is proposed.
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