期刊
ANALYST
卷 134, 期 4, 页码 719-724出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b814967d
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资金
- European Commission [NMP4-CT-2005-516981]
- Swedish Research Council
- Div Of Chem, Bioeng, Env, & Transp Sys [0854105] Funding Source: National Science Foundation
A single bi-functional monomer, N, O-bismethacryloyl ethanolamine (NOBE), was used in precipitation polymerization system to synthesize molecularly imprinted polymer (MIP) microspheres. Highly specific binding sites were obtained for N-terminal protected neuropeptides, Boc-Leu-enkephalin and Pyr-Leu-enkephalin. The use of NOBE allowed binding sites to be formed in polymer microspheres that are able to recognize target peptides through the consensus C-terminal sequence. The interesting molecular binding results suggest a new approach for peptide analysis combining in situ chemical modification with MIP recognition under non-aqueous conditions.
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