期刊
JOURNAL OF BIOMEDICAL OPTICS
卷 12, 期 5, 页码 -出版社
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.2800294
关键词
magnetic resonance imaging; fluorescent probes; iron oxide particles; optical imaging
资金
- Intramural NIH HHS [Z01 NS003047-01] Funding Source: Medline
Iron oxide particles are becoming an important contrast agent for magnetic resonance imaging (MRI) cell tracking studies. Simultaneous delivery of fluorescence indicators with the particles to individual cells offers the possibility of correlating optical images and MRI. In this work, it is demonstrated that micron-sized iron oxide particles (MPIOs) can be used as a carrier to deliver fluorescent probes to cells in culture as well as to migrating neural progenitors in vivo. Migrating progenitors were tracked with MRI and easily identified by histology because of the fluorescent probe. These data suggest that using MPIOs to deliver fluorescent probes should make it possible to combine MRI and optical imaging for in vivo cell tracking. (c) 2007 Society of Photo-Optical Instrumentation Engineers.
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