期刊
ANALYST
卷 134, 期 8, 页码 1536-1540出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b907039g
关键词
-
资金
- Marie Curie Intra European Fellowship [PIEF-GA-2008219222]
We present an inexpensive method and apparatus for the deposition of analytes separated by capillary electrophoresis (CE) onto a custom-designed matrix-assisted laser desorption/ionization (MALDI) target plate. This dedicated CE-MALDI plate is coated with an omniphobic polysilazane nanocoating and has an array of parallel grooves acting as recipients of the separation effluent. The 3-D pattern in the top layer of the coated plate greatly improves loading of the matrix solution prior to separation and facilitates deposition of the separated species. We demonstrate application of this straightforward protocol to the analysis of metabolites from the central metabolic pathway in a complex biological sample spiked with small molecule standards.
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