期刊
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
卷 38, 期 -, 页码 S23-S33出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0020-1383(08)70006-8
关键词
mesenchymal stem cells; bone repair; culture; implantation
Mesenchymat stem cells (MSCs) are undifferentiated multipotent cells which reside in various human tissues and have the potential to differentiate into osteobtasts, chondrocytes, adipocytes, fibroblasts and other tissues of mesenchymat origin. In the human body they could be regarded as readily available reservoirs of reparative cells capable to mobilize, proliferate and differentiate to the appropriate cell type in response to certain signals. These properties have triggered a variety of MSC-based therapies for pathologies including nonunions, osteogenesis imperfecta, cartilage damage and myocardial infarction. The outcome of these approaches is influenced by the methodologies and materials used during the cycle from the isolation of MSCs to their re-implantation. This review article focuses on the pathways that are followed from the isolation of MSCs, expansion and implantation. (C) 2007 Elsevier Ltd. All rights reserved
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