期刊
SYNTHESIS-STUTTGART
卷 -, 期 17, 页码 2746-2750出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2007-983780
关键词
Reformatsky reaction; enantioselective; catalysis; chloromanganese-Salen complex; dimethylzinc
The first catalytic enantioselective Reformatsky reaction is realized by a controlled transmetalation of an a-iodo ester with dimethylzinc in the presence of a chloromanganese-Salen complex (20 mol%) as catalyst and 4-phenylpyridine N-oxide (25 mol%) as additive. The zinc enolate is formed under mild conditions at room temperature; it undergoes enantioselective addition to ketones. The reaction shows broad scope and moderate to good stereoselection and it allows the straightforward preparation of quaternary stereogenic centers.
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