History of childhood maltreatment is associated with comorbid depression in women with migraine

Background: A bidirectional relationship between migraine and depression suggests a neurobiological link. Adverse experiences, particularly childhood maltreatment, may alter neurobiological systems, and predispose to a multiplicity of adult chronic disorders. Our objective is to determine, within a headache clinic population of women, if depression moderates the abuse- migraine relationship. Methods: At six headache specialty clinics, women with migraine were diagnosed using ICHD-II criteria, and frequency was recorded. A questionnaire regarding maltreatment history, headache characteristics, current depression, and somatic symptoms was completed. Results: A total of 949 women with migraine completed the survey: 40% had chronic headache ( >= 15 headache days/month) and 72% had very severe headache-related disability. Major depression was recorded in 18%. Physical or sexual abuse was reported in 38%, and12% reported both physical and sexual abuse in the past. Migraineurs with current major depression reported physical ( p < 0.001) and sexual ( p < 0.001) abuse in higher frequencies compared to those without depression. Women with major depression were more likely to report sexual abuse occurring before age 12 years ( OR = 2.30, 95% CI: 1.14 to 4.77), and the relationship was stronger when abuse occurred both before and after age 12 years ( OR = 5.08, 95% CI: 2.15 to 11.99). Women with major depression were also twice as likely to report multiple types of maltreatment ( OR = 2.07, 95% CI: 1.27 to 3.35) compared to those without depression. Conclusions: Childhood maltreatment was more common in women with migraine and concomitant major depression than in those with migraine alone. The association of childhood sexual abuse with migraine and depression is amplified if abuse also occurs at a later age.