期刊
VACCINE
卷 25, 期 36, 页码 6635-6645出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2007.06.036
关键词
malaria; DNA vaccine; electroporation
We evaluated the effectiveness of in vivo electroporation (EP) for the enhancement of immune responses induced by DNA plasmids encoding the pre-erythrocytic Plasmodium yoelii antigens PyCSP and PyHEP17 administered intramuscularly and intradermally to mice. EP resulted in a 16- and 2-fold enhancement of antibody responses to PyCSP and PyHEP 17, respectively. Immunization with 5 mu g of DNA via EP was equivalent to 50 mu g of DNA via conventional needle, thus reducing by 10-fold the required dose to produce a given effect. Moreover, IFN-gamma responses were increased by approximately 2-fold. Data demonstrate the potential of EP to enhance immune responses to DNA vaccines against infectious agents. (c) 2007 Elsevier Ltd. All rights reserved.
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