期刊
POWDER TECHNOLOGY
卷 178, 期 1, 页码 40-50出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.powtec.2007.03.046
关键词
spray-drying; salbutamol sulphate; amino acids; dispersibility; pulmonary deposition
资金
- Engineering and Physical Sciences Research Council [EP/C003020/1] Funding Source: researchfish
In this study, the amino acids arginine, aspartic acid, leucine, phenylalanine and threonine were investigated as 'dispersibility enhancers' in spray-dried powders for inhalation. Parameters such as spray-dried yield, tapped density, and Carr's Index were not predictive of aerosolisation performance. In addition, whilst the majority of amino acid-modified powders displayed suitable particle size distribution for pulmonary administration and potentially favourable low moisture content, in vitro particle deposition was only enhanced for the leucine-modified powder. In summary, leucine can be used to enhance the dispersibility, and aerosolisation properties of spray-dried powders for pulmonary drug delivery. (c) 2007 Elsevier B.V All rights reserved.
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