期刊
EMBO JOURNAL
卷 26, 期 17, 页码 3888-3899出版社
WILEY
DOI: 10.1038/sj.emboj.7601819
关键词
GABA(A) receptor; gephyrin; glycine receptor; GEF; long-term potentiation; spatial memory
资金
- Medical Research Council [G0601585, G0501258] Funding Source: researchfish
- MRC [G0501258, G0601585] Funding Source: UKRI
- Medical Research Council [G0601585, G0501258] Funding Source: Medline
Collybistin (Cb) is a brain-specific guanine nucleotide exchange factor that has been implicated in plasma membrane targeting of the postsynaptic scaffolding protein gephyrin found at glycinergic and GABAergic synapses. Here we show that Cb-deficient mice display a region-specific loss of postsynaptic gephyrin and GABA(A) receptor clusters in the hippocampus and the basolateral amygdala. Cb deficiency is accompanied by significant changes in hippocampal synaptic plasticity, due to reduced dendritic GABAergic inhibition. Long-term potentiation is enhanced, and long-term depression reduced, in Cb-deficient hippocampal slices. Consistent with the anatomical and electro-physiological findings, the animals show increased levels of anxiety and impaired spatial learning. Together, our data indicate that Cb is essential for gephyrin-dependent clustering of a specific set of GABA(A) receptors, but not required for glycine receptor postsynaptic localization.
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