期刊
JOURNAL OF NEUROSCIENCE
卷 27, 期 36, 页码 9648-9652出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2655-07.2007
关键词
critical period; layer IV; layer II/III; LTP; LTD; plasticity
资金
- NEI NIH HHS [R01 EY012124, R01-EY12124] Funding Source: Medline
Visual deprivation affects the responses of layer IV cells more prominently during early postnatal development, whereas responses in layer II/III remain modifiable until later ages. We examined whether these laminar differences correlate with changes in long-term potentiation ( LTP) and long-term depression ( LTD) of the ascending pathways to layers IV and II/III in the mouse visual cortex. Our analysis revealed that LTP and LTD in layer IV principal cells is lost shortly after the eyes open, but persists in layers II/III beyond puberty. These results suggest that plasticity proceeds sequentially through cortical layers in a manner that parallels the flow of information during sensory processing.
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