期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 342, 期 1-2, 页码 1-5出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2007.03.056
关键词
2-pyrrolidone; solubilization; cosolvency; complexation
The solubilization of nine poorly soluble compounds in aqueous solution by 2-pyrrolidone has been studied. Solubility enhancement as high as 500-fold is achieved using 20% 2-pyrrolidone. A comparison shows that 2-pyrrolidone is a better solubilizer than glycerin, propylene glycol, polyethylene glycol 400 or ethanol. The observed solubilization curves are deconvoluted into components representing complexation and cosolvency. A clear linear relationship exists between the cosolvency solubilization power (a) of 2-pyrrolidone and the partition coefficient (log K-ow) of the drug (R-2 = 0.96) extending over three orders of magnitude. The stability constants for the formation of 1: 1 complex (K-1:1) involving 2-pyrrolidone and the drugs have been calculated. A weaker correlation (R-2 = 0.74) is observed between the complexation constants and the partition coefficients of respective drugs. This study indicates that 2-pyrrolidone, like NMP, can act as a complexant at low concentrations and as a cosolvent at high concentrations and that both these properties are affected by the partition coefficient of the solute. Published by Elsevier B.V.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据