期刊
MOLECULAR CELL
卷 27, 期 5, 页码 793-805出版社
CELL PRESS
DOI: 10.1016/j.molcel.2007.07.009
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资金
- NIGMS NIH HHS [GM053759, R01 GM075273, R01 GM075273-02, R01 GM053759] Funding Source: Medline
A transcriptional response to singlet oxygen in Rhodobacter sphaeroides is controlled by the group IV sigma factor sigma(E) and its cognate anti-sigma ChrR. Crystal structures of the sigma(E)/ChrR complex reveal a modular, two-domain architecture for ChrR. The ChrR N-terminal anti-sigma domain (ASID) binds a Zn2+ ion, contacts sigma(E), and is sufficient to inhibit sigma(E)-dependent transcription. The ChrR C-terminal domain adopts a cupin fold, can coordinate an additional Zn2+, and is required for the transcriptional response to singlet oxygen. Structure-based sequence analyses predict that the ASID defines a common structural fold among predicted group IV antias. These ASDs are fused to diverse C-terminal domains that are likely involved in responding to specific environmental signals that control the activity of their cognate sigma factor.
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