期刊
BMJ-BRITISH MEDICAL JOURNAL
卷 335, 期 7618, 页码 486-489出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/bmj.39303.723449.55
关键词
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资金
- Economic and Social Research Council [ES/E004164/1] Funding Source: researchfish
- Medical Research Council [G0001164, MC_U106179474] Funding Source: researchfish
- ESRC [ES/E004164/1] Funding Source: UKRI
- MRC [MC_U106179474, G0001164] Funding Source: UKRI
- Medical Research Council [MC_U106179474, G0001164] Funding Source: Medline
- Wellcome Trust [071200/Z/03/Z, G0000753] Funding Source: Medline
Objective To quantify the psychological impact of primary care based stepwise screening for type 2 diabetes. Design Controlled trial and comparative study embedded in a randomised controlled trial. Setting 15 practices (10 screening, five control) in the ADDITION (Cambridge) trial in the east of England. Participants 7380 adults (aged 40-69) in the top fourth for risk of having undiagnosed type 2 diabetes (6416 invited for screening, 964 controls). Interventions Invited for screening for type 2 diabetes or not invited (controls), incorporating a comparative study of subgroups of screening attenders. Attenders completed questionnaires after a random blood glucose test and at 3-6 months and 12-15 months later. Controls were sent questionnaires at corresponding time points. Non-attenders were sent questionnaires at 3-6 months and 12-15 months. Main outcome measures State anxiety (Spietberger state anxiety inventory), anxiety and depression (hospital anxiety and depression scale), worry about diabetes, and self rated health. Results No significant differences were found between the screening and control participants at any time-for example, difference in means (95% confidence intervals) for state anxiety after the initial blood glucose test was -0.53, -2.60 to 1.54, at 3-6 months was 1.51 (-0.17 to 3.20), and at 12-15 months was 0.57, -1.11 to 2.24. After the initial test, compared with participants who screened negative, those who screened positive reported significantly poorer general health (difference in means -0.19, -0.25 to -0.13), higher state anxiety (0.93, -0.02 to 1.88), higher depression (0.32, 0.08 to 0.56), and higher worry about diabetes (0.25, 0.09 to 0.41), although effect sizes were small. Small but significant trends were found for self rated health across the screening subgroups at 3-6 months (P=0.047) and for worry about diabetes across the screen negative groups at 3-6 months and 12-15 months (P=0.001). Conclusions Screening for type 2 diabetes has limited psychological impact on patients. Implementing a national screening programme based on the stepwise screening procedure used in the ADDITION (Cambridge) trial is unlikely to have significant consequences for patients' psychological health.
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