期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 72, 期 19, 页码 7352-7358出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo0710883
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资金
- NIGMS NIH HHS [R01 GM 65961-01] Funding Source: Medline
[GRAPHICS] A concise route toward the syntheses of (-)-drupacine and (+)- and (-)-cephalotaxine has been developed. The syntheses rely on Pd(II)-catalyzed aerobic oxidative heterocyclization chemistry, which was employed to rapidly construct an important spirocyclic amine intermediate. A dynamic beta-elimination/conjugate addition process was strategically applied to complete the first asymmetric total synthesis of (-)-drupacine.
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