期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 72, 期 19, 页码 7469-7472出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo7012862
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[GRAPHICS] A practical and efficient protocol for the three-step synthesis of (S)-N-ethoxycarbonyl-alpha-.methylvaline 3 is described which utilizes readily available commercial starting materials. The key transformations involve resolution-crystallization of tartrate salt 6 followed by a one-pot procedure for the preparation of 3 which is isolated as the dicyclohexylamine salt in 45% overall yield and in 91-95% ee.
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