Volumetric neuroimage analysis extensions for the MIPAV software package

We describe a new collection of publicly available software tools for performing quantitative neuroimage analysis. The tools perform semiautomaticrain extraction, tissue classification, Talairach alignment, and atlas-based measurements within a user-friendly graphical environment. They are implemented as plug-ins for MIPAV, a freely available medical image processing software package from the National Institutes of Health. Because the plug-ins and MIPAV are implemented in Java, both can be utilized on nearly any operating system platform. In addition to the software plug-ins. we have also released a digital version of the Talairach atlas that can be used to perform regional volumetric analyses. Several studies are conducted applying the new tools to simulated and real neuroimaging data sets. (c) 2007 Elsevier B.V. All rights reserved.