Synthesis and SAR studies of novel antifungal 1,2,3-triazines

A novel series of pyridothieno-1,2,3-triazines with potent antifungal activity against Erysiphe graminis f sp. tritici has been discovered. Two complementary synthetic routes to compounds of this type have been developed and used to efficiently explore the structure-activity relationships around the lead compound. The incorporation of oxygen atoms into the side chains of the molecules has allowed the solubility of the compounds to be increased 10-fold whilst retaining biological activity. (c) 2007 Elsevier Ltd. All rights reserved.