期刊
JOURNAL OF IMMUNOLOGY
卷 179, 期 6, 页码 3402-3406出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.179.6.3402
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资金
- NCI NIH HHS [R01 CA80105, R01 CA080105-07S3, R01 CA080105-07, R01 CA080105-06S1, R01 CA080105-07S2, R01 CA080105, R01 CA080105-05, R01 CA080105-07S1, R01 CA080105-06] Funding Source: Medline
Cytokine-induced tyrosine phosphorylation of the transcription factor STAT5 is required for its transcriptional activity. In this article we show that the small dual-specificity phosphatase VHR selectively dephosphorylates IFN-alpha- and beta-activated, tyrosine phosphorylated STAT5, leading to the subsequent inhibition of STAT5 function. Phosphorylation of VHR at Tyr(138) was required for its phosphatase activity toward STAT5. In addition, the Src homology 2 domain of STAT5 was required for the effective dephosphorylation of STAT5 by VHR The tyrosine kinase Tyk2, which mediates the phosphorylation of STAT5, was also responsible for the phosphorylation of VHR at Tyr(138).
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