期刊
JOURNAL OF INFECTIOUS DISEASES
卷 196, 期 6, 页码 835-843出版社
OXFORD UNIV PRESS INC
DOI: 10.1086/521027
关键词
-
资金
- NIAID NIH HHS [R21 AI067327, U19AI62623] Funding Source: Medline
The innate immune system mounts the first host response to pathogens. Because alpha-defensins, which are cationic antimicrobial peptides of polymorphonuclear neutrophils and other leukocytes, are important effectors of the innate immune system, we studied the antiviral activity of human (x-defensin-l (also known as human neutrophil peptide-1 [HNP-1]) against influenza virus in vitro. Treatment of cell cultures with HNP-1 soon after infection resulted in marked inhibition of influenza virus replication and viral protein synthesis. This effect was not due to cytotoxicity or to a direct effect on the virus. Treatment of cells with HNP-1 followed by its removal before infection also inhibited viral replication, suggesting that the inhibition was due to the modulation of cellular pathways. HNP-1 treatment inhibited protein kinase C (PKC) activation in infected cells, suggesting the involvement of the PKC pathway. Our data expand the previously known activity of cedefensins against influenza virus. Characterizing the mechanism of action of alpha-defensins may lead to the identification of new strategies for prevention and therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据