期刊
BIOLOGICAL PSYCHIATRY
卷 62, 期 6, 页码 600-606出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2006.11.028
关键词
amygdala; ASL perfusion fMRI; cerebral blood flow; depression; ventromedial orbitofrontal cortex
资金
- NICHD NIH HHS [R01 HD 043078, P30 HD 26904-S2] Funding Source: Medline
- NIDA NIH HHS [R21 DA 01586, R01 DA 14129, R01 DA 18913] Funding Source: Medline
- NIMH NIH HHS [F31 MH 073363-01A1, K08 MH 068586, R21 MH 072576] Funding Source: Medline
- NINDS NIH HHS [P30 NS 045839] Funding Source: Medline
Background: Perfusion functional magnetic resonance imaging (fMRI) was used to investigate the effect of genetic variation of the human serotonin transporter (5-HTT) gene (5-HTTLPR, SLC6A4) on resting brain function of healthy individuals. Methods: Twenty-six healthy subjects, half homozygous for the 5-HTTLPR short allele (s/s group) and half homozygous for the long allele (I/I group), underwent perfusion functional and structural magnetic resonance imaging during a resting state. The two genotype groups had no psychiatric illness and were similar in age, gender, and personality scores. Results: Compared with the I/I group, the s/s group showed significantly increased resting cerebral blood flow (CBF) in the amygdala and decreased CBF in the ventromedial prefrontal cortex. The effect of functional modulation in these regions by 5-HTTLPR genotype cannot be accounted for by variations in brain anatomy, personality, or self-reported mood. Conclusions: The 5-HTTLPR genotype alters resting brain function in emotion-related regions in healthy individuals, including the amygdala and ventromedial prefrontal cortex. Such alterations suggest a broad role of the 5-HTT gene in brain function that may be associated with the genetic susceptibility for mood disorders such as depression.
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