期刊
DEVELOPMENTAL BIOLOGY
卷 309, 期 2, 页码 306-316出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2007.07.019
关键词
arabidopsis; homeodomain; pattern formation; WUSCHEL; WOX genes; STIMPY; genetic redundancy
资金
- NIGMS NIH HHS [R01 GM062932-06, GM62932, R01 GM062932] Funding Source: Medline
Tissue growth as the result of cell division is an essential part of embryonic development. Previous studies have shown that STIMPY (STIP)/ WOX9, a homeodomain transcription factor of the Arabidopsis thaliana WOX family, is required for maintaining cell division and preventing premature differentiation in emerging seedlings. Here we present evidence that STIP performs similar functions during embryogenesis. Complete loss of STIP activity results in early embryonic arrest, most likely due to a failure in cell division. STIMPY-LIKE (STPL)/WOX8, a close homolog of STIP in Arabidopsis, also positively regulates early embryonic growth and can replace STIP function when expressed under the STIP promoter. STPL shares redundant functions with a more distantly related member of the WOX family, WOX2, in regulating embryonic apical patterning. These findings show that combinatorial action of WOX transcription factors is essential for Arabidopsis embryonic development. (C) 2007 Elsevier Inc. All rights reserved.
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