期刊
BIOLOGICAL PSYCHIATRY
卷 62, 期 6, 页码 698-701出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2006.10.018
关键词
dorsolateral prefrontal cortex; fMRI; hypothalamus; neural mechanism; pedophilia; periaqueductal gray
Background: Although pedophilia is of high public concern, little is known about underlying neural mechanisms. Although pedophilic patients are sexually attracted to prepubescent children, they show no sexual interest toward adults. This study aimed to investigate the neural correlates of deficits of sexual and emotional arousal in pedophiles. Methods: Thirteen pedophilic patients and 14 healthy control subjects were tested for differential neural activity during visual stimulation with emotional and erotic pictures with functional magnetic resonance imaging. Results: Regions showing differential activations during the erotic condition comprised the hypothalamus, the periaqueductal gray, and dorsolateral prefrontal cortex, the latter correlating with a clinical measure. Alterations of emotional processing concerned the amygdala hippocampus and dorsomedial prefrontal cortex. Conclusions: Hypothesized regions relevant for processing of erotic stimuli in healthy individuals showed reduced activations during visual erotic stimulation in pedophilic patients. This suggests an impaired recruitment of key structures that might contribute to an altered sexual interest of these patients toward adults.
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